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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Abstract

Background

kok体育官方网站Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.

Patients and methods

French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16thkok体育官方网站, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.

Results

Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.

kok体育官方网站Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.

Conclusion

kok体育官方网站Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

Key words

2019-nCoV
SARS-CoV-2
COVID-19
Hydroxychloroquine
Azithromycin
Clinical trial

kok体育官方网站Given his role as Editor in Chief of this journal, Jean Marc Rolain had no involvement in the peer-review of this article and has no access to information regarding its peer-review. Full responsibility for the peer-review process for this article was delegated to P.R. Hsueh.

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